For which type of patients are third doses and booster doses particularly recommended?

Third doses and booster doses are particularly recommended for immunocompromised patients, especially those receiving mRNA vaccines, due to their decreased immune response to the initial vaccination series. This population includes individuals with conditions that compromise their immune systems, such as certain cancers, organ transplant recipients, or those receiving immunosuppressive therapy.

Studies have shown that these patients may not achieve adequate protective antibody levels after the standard two-dose series, leaving them at a heightened risk for severe COVID-19. The additional dose aims to enhance their immune response and provide better protection.

While other groups, including all adults, individuals over 65, and pediatric patients may also benefit from additional doses under certain circumstances, the recommendation for immunocompromised patients is more urgent and specific due to their unique vulnerability and the documented need for enhanced immunity.