What over-the-counter medications may be recommended to treat systemic reactions after vaccination?

The recommendation of NSAIDs (nonsteroidal anti-inflammatory drugs) and acetaminophen for treating systemic reactions after vaccination is based on their effectiveness in alleviating symptoms such as fever, headache, and muscle aches that may occur as a response to the vaccine. These medications can help to reduce inflammation and provide comfort to individuals experiencing post-vaccination reactions.

Acetaminophen is often suggested because it is effective for pain and fever relief, while NSAIDs can also reduce inflammation. Both medication classes are generally considered safe for most individuals post-vaccination and can be taken as needed to manage mild to moderate discomfort.

In contrast, the other options do not serve the same purpose effectively. Loperamide and bismuth subsalicylate are more suited for treating gastrointestinal symptoms and do not address systemic reactions. Dextromethorphan and cetirizine are primarily used for cough suppression and allergic reactions, respectively, rather than systemic reactions related to vaccines. Diphenhydramine, an antihistamine, primarily helps with allergic reactions and may not be the first choice for systemic vaccine reactions, while guaifenesin is an expectorant for relieving respiratory mucus and does not address the systemic symptoms that might arise after vaccination.