Which vaccine-related symptom is typically classified as local rather than systemic?

The symptom typically classified as local rather than systemic is tenderness. Local reactions to vaccines often occur at the site of administration and include symptoms like tenderness, redness, and swelling. Tenderness specifically indicates localized inflammation and is a direct response to the injection.

In contrast, fever, angioedema, and wheezing are classified as systemic reactions. Fever is a common systemic response to immunization as it reflects the body's overall immune response to the vaccine. Angioedema and wheezing are signs of allergic reactions, which can also affect the whole body rather than being limited to the injection site. Therefore, tenderness stands out as the local symptom in this context.